Tổng hợp và thử tác dụng kháng nấm của 2-amino-4,7,9 trihydroxy[1]benzofuro[3,2-d] pyrimidin-6-carbonitril

Invasive fungal infections are a major cause of death worldwide, especially in vulnerable patients. Candida albicans is one of the species involved in invasive fungal infections, with a very high mortality rate. In this study, we focused specifically on fluconazole-resistant strains. In search for fungicidal agents for the  treatment of invasive  fungal infections, benzofuro[3,2-d]pyrimidin (7),  derived from  (-)- cercosporamide, is synthesized in 6 steps by well – known reactions. Compound 7 showed inhibitory activity of CAAL 28 with IC₅₀ of 30.27 μM.

Keywords: Dihydroxybenzofuran, antifungal activity, Candida albicans, fluconazol.

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