NGHIÊN CỨU BÀO CHẾ HỆ VI TỰ NHŨ CHỨA BERBERIN

Summary

Berberine (BER) is natural isoquinoline alkaloid, reported to possess numerous pharmacological activities including hyperlipidemia, diabetes, metabolic syndrome, obesity, fatty liver disease. However, BER shows low bioavailability because of poor solubility and poor permeability. The purpose of this study was to enhance the dissolution rate of BER by developing a novel delivery system that is self-microemulsifying drug delivery system (SMEDDS). Pseudoternary phase diagrams were constructed using oil, surfactant and co-surfactant types to identify the efficient selfmicroemulsification region. The optimal formulation with the best self-microemulsifying and solubilization ability consisted of 19.5 % (w/w) of Peceol, 39 % (w/w) Cremophor RH 40.39 % (w/w) propylen glycol and 2.5 % BER (w/w). SMEDDS was characterized by morphological observation, droplet size, stability, drug content and in vitro release. The SMEDDS of BER could exhibit good stability. In vitro release test showed a complete release of BER from SMEDDS was in 30 minutes. These results demonstrate the potential use of SMEDDS for improving the bioavailability of BER.

Keywords: Berberin chlorid, self-microemulsifying drug delivery system, phase diagrams, Chemix 3.6.

Đầu trang

Tải