Nghiên cứu sàng lọc tá dược bào chế cốt dính trên da chứa lornoxicam

The objective of study was to apply quality by design approach to screen critical exicipients for formulation of drug-in-adhesive matrix system containing lornoxicam. Based on ANOVA analysis of experimental results using the software (MODDE 12.0), the effect of input variables (ratio of triethanolamine, Cremophor RH 40, Al(OH)₃, Transcutol, and kinds of acidic agent (citric and tartaric acid) on the ouput variables (solubility and flux of drug, adhesive ability and surface pH of system) was investigated. The obtained results of this study have potential for optimization of an analgesic patch containing lornoxicam in further studies.

Keywords: Matrix, lornoxicam, triethanolamine, Transcutol, Cremophor RH40.

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