TÁC ĐỘNG ỨC CHẾ HOẠT TÍNH ENZYM XANTHIN OXIDASE VÀ CHỐNG OXY HÓA IN VITRO CỦA CAO CÚC CHÂN VỊT (SPHAERANTHUS AFRICANUS L.)

Summary
Gout is a fairly common inflammatory arthritis in Vietnam and around the world. The study was for evaluation of in vitro xanthin oxidase inhibitory and antioxidant activity of total ethanol extract and the fractions of Sphaeranthus africanus L. The results showed that total ethanol extract and all of the fractions of n-hexane, chloroform, ethyl acetate, buthanol, water had in vitro xanthin oxidase inhibitory and antioxidant activity. In which, ethyl acetat extract had the highest effect with IC₅₀ of 651.38 ± 14.59 µg/ml in xanthine oxidase inhibition test (higher than that of allopurrinol 1.56 ± 0.06 µg/ml) and IC₅₀ of 51.55 ± 1.79 µg/ml in the antioxidant test (higher than that of vitamine C 35.15 ± 0.29 µg/ml).
Keywords: Sphaeranthus africanus L., xanthine oxidase, antioxidant.

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