Tổng hợp các tác nhân tiềm năng kháng nấm 1,5-diaryl-1H-imidazol

As antifungal activity of heterocyclic 1H-imidazole, inclusive of 1,5-diaryl-1H-imidazole derivatives, is increasingly concerned, 1,5-diaryl-1H-imidazole derivatives were prepared by two synthetical pathways: One by condensation reaction of imines and p-tosylmethyl isocyanide (TosMIC), in which imine derivatives were synthesized to serve as intermediate products, and the other by oxidation of 1,5-diaryl-1H-imidazole derivatives with methylthio substituent. Thereby, 16 imine derivatives and 23 derivatives of 1,5-diaryl-1H-imidazole were obtained and structurally defined. These compounds would be subjected to future studies on evaluation of their antifungal activity.
Keywords: Imine, 1,5-diaryl-1H-imidazole, TosMIC, heterocyclic ring, antifungal.

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