TỔNG HỢP VÀ KHẢO SÁT HOẠT TÍNH KHÁNG STAPHYLOCOCCUS AUREUS CỦA KHUNG CẤU TRÚC HYDRAZID-HYDRAZON VÀ 1,3,4-OXADIAZOL MANG DỊ VÒNG 5,7-DIBROMOBENZOFURAN

Summary
In this study, 8 derivatives of hydrazide-hydrazone and 1,3,4-oxadiazole containing 5,7-dibromobenzofuran ring (6a–d, 7a–d) were successfully synthesized using the classic acidcatalyzed condensation of 5,7-dibromobenzofuran-2-carbohydrazide with benzaldehydes and followed by transition-metal-free oxidative cyclization. The structures of synthesized products that characterized by IR, MS, ¹H-NMR and ¹³C-NMR spectra, are consistent with the target products. The anti-Staphylococcus aureus activity screening results showed that replacing the 2-ketone bridge with the hydrazide-hydrazone as well as the 1,3,4-oxadiazole heterocyclic, the anti-S. aureus activity will be decreased or completely lost.
Keywords:      5,7-dibromobenzofuran-2-yl-1,3,4-oxadiazole,              5,7-dibromobenzofuran-2-carbohydrazone, hydrazide-hydrazone, oxadiazole, Staphylococcus aureus, MRSA

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