Tổng hợp và thử hoạt tính gây độc tế bào ung thư của một số dẫn chất isatin

In this study, a series of isatin aldazine derivatives (2a-d) was synthesized by the condensation of 3-hydrazonoindolin-2-on (1) with substituted aromatic aldehydes. Their structural identification was based on 2D-NMR and MS data. The in vitro cytotoxic activities of all synthesized compounds against human colon adenocarcinoma cells (HT-29) were evaluated by the SRB assay. The result showed that all compounds exhibited no activity against the tested cell lines.

Keywords: Isatin derivatives, synthesis, cytotoxic activity, human colon adenocarcinoma cells, HT-29.

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