TẦM SOÁT BIẾN CỐ GIẢM TIỂU CẦU LIÊN QUAN ĐẾN LINEZOLID THÔNG QUA KẾT QUẢ XÉT NGHIỆM HUYẾT HỌC TẠI BỆNH VIỆN BẠCH MAI

Summary

This study was aimed to screen and identify linezolid – induced thrombocytopenia in hospitalized patients based on laboratory database and to describe characteristics of these case. This was a descriptive-restropective study of inpatients at Bach Mai hospital. These patients had a platelet count < 150 G/L and used linezolid based on laboratory database and electronic medical record were collected in 2019. The cases of linezolid-induced thrombocytopenia were defined according to the WHO – UMC causality assessment method. Of 4830 thrombocytopenia cases, 146 suspected linezolid-induced thrombocytopenia (3.0 %) cases were identified. The incidence of linezolid-induced thrombocytopenia in patients treated with linezolid was 146/2172 (6.7 %) which corresponding to 146/165644 (0.09 %) inpatients during the study period. The severity of thrombocytopenia in most of the cases were classified as mild (63.7 %), with lag time of more than 1 weeks (71.2 %) and the time to be resolved within one week (50.7 %). In conclusion, the screening laboratory test result were found to be adjunctive approach to identify cases suspected with linezolid-induced thrombocytopenia, which is often under – reporting by the spontaneous reporting system.

Keywords: Thrombocytopenia, linezolid, adverse drug reactions, screening laboratory test result.

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